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Immune response to IVIG in patients with Kawasaki disease & MIS-C
IVIG targets IL-1b+ neutrophils via non-apoptotic cell death


Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C. The Journal of Clinical Investigation 2021; 131(20):e147076. PMID: 34464357.

RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis
RIPK1 deficiency induces RIPK3- and Caspase-8-dependent deletion of hematopoietic stem cells and hematopoietic progenitor cells following transplantation


Rickard et al., RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell 2014, 157(5): 1175-88. PMID:24813849


Reviewed in Berndt et al., Science Signaling 2015, 8(358):1. 2014: Signaling Breakthroughs of the Year. PMID: 25564676


Necroptotic NETS Croker2018 color.jpg
The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
Neutrophil necroptosis generates a specialized form of neutrophil extracellular trap (NET)


A D’Cruz et al., The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Science Signaling, 11, eaao1716 (2018). PMID: 30181240

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. 
SARS-CoV-2 induces apoptotic cell death of infected cells 

Z Inde*, BA Croker* et al. Science Advances 2021,7(34):eabf8609. *contributed equally. PMID:34407940

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
Ptpn6 negatively regulates p38 MAPK activation to control TNF and IL-1α/β expression, and maintains Ripk1 function to prevent caspase-8- and Ripk3–Mlkl-dependent cell death and concomitant IL-1α/β release.


Speir et al. Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nature Immunology 2020, 21, 54-64. PMID: 31819256

Comment in Science 2020, 367(6475): 261-262. 

Croker SHP1 Live Cell PTPN6 UCSD.png
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  56. Zhu et al., Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C. The Journal of Clinical Investigation 2021; 131(20):e147076. PMID: 34464357

  57. Li et al., Conformational flexibility in neutralization of SARS-CoV-2 by naturally-elicited anti-SARS-CoV-2 antibodies. Communications Biology 2022, 5(1):789. PMID:35931732

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