We study inflammatory forms of cell death in immune cells during normal blood formation, inflammatory disease, infection, asthma, and leukemogenesis.
The life and death of neutrophils
The production, function, and death of neutrophils is critical for host defense against pathogens. We investigate how neutrophils regulate inflammation in disease. Our current research investigates the role of inflammatory cell death signaling in neutrophil cytokine secretion, NET formation, and neutrophil lifespan. The laboratory also studies a novel phenomena called shuttling, which involves the transfer of intracellular pathogens from neutrophils to macrophages.